L'Osservatore Romano this week congratulated the show on its 20th anniversary, praising its philosophical leanings as well as its stinging and often irreverent take on religion.
Without Homer Simpson and all those other yellow-skinned characters, ''many today wouldn't know how to laugh,'' said the article, titled ''Aristotle's virtues and Homer's doughnut''.
The paper credited The Simpsons - the longest-running American animated program - with opening up cartoons to an adult audience.
The show is based on ''realistic and intelligent writing'', it said, though it added there was some reason to criticise its ''excessively crude language, the violence of certain episodes or some extreme choices by the scriptwriters''.
Religion, from the snore-evoking sermons of the Reverend Lovejoy to Homer's face-to-face talks with God, appears so frequently on the show that it could be possible to come up with a ''Simpsonian theology'', it said.
Homer's religious confusion and ignorance are ''a mirror of the indifference and the need that modern man feels toward faith'', the paper said.
It commented on several religion-themed episodes, including one in which Homer calls for divine intervention by crying: ''I'm not normally a religious man, but if you're up there, save me, Superman!''
''Homer finds in God his last refuge, even though he sometimes gets His name sensationally wrong,'' L'Osservatore said.
The Vatican's seal of approval is not the first unlikely endorsement for one of the world's great non-role models. The character who lives for doughnuts and beer, Homer Simpson, has been used by the British Health Department in a $1 million campaign to promote its anti-obesity message.